Endocrine Abstracts

The free fatty acid 4 receptor (FFA4R) is highly expressed in adipose tissue and other tissues that are involved in metabolic homeostasis, where its pharmacological stimulation improves glucose uptake and insulin sensitivity. Work by our and other groups have revealed that, contrary to textbook knowledge, GPCRs are not only active at the plasma membrane, as previously believed, but also at intracellular sites such as early endosomes or the Golgi complex/trans-Golgi network. Ho...